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The Lee-Benner Institute is offering Fellowship positions to outstanding candidates who have a strong career interest in Antiaging Medicine. These unique two year training programs are under the direction and personal supervision of Lord Lee-Benner, M.D., F.A.C.E.

Earn 100 Category 1 American Medical Association Continuing Medical Education (CME) Credits.

Dr. Lee-Benner’s credentials (C.V.) can be viewed at www.theantiagingdoctor.com

Reinventing Your Clinical Practice

To Meet the Challenges Facing Medical Practitioners Today

Lee-Benner Institute Two Year Fellowship Program

This prestigious program begins with a high caliber, intensive one week course in the Art and Science of Antiaging Medicine at Newport Beach, CA. The candidates then will return to their own practice area for the two year supervisory period. Candidates who successfully present longitudinal studies and clinical data on 10 of their own patients at the end of the two year period will be awarded the honor of being appointed a Fellow of the LBI for Antiaging Medicine. The successful candidate will receive a Certificate of satisfactory completion of the 2 years fellowship program attesting they have been accepted and inducted as a Clinical Fellow of the Lee-Benner Institute for Antiaging Medicine with full honors and privileges thereof.

A Certificate certifying satisfactory completion of the one week intensive course in the Art and Science of Antiaging Medicine and acceptance as a Candidate for the Clinical Fellowship will be presented at that time.


Course Name: Clinical Interventions for the Changes Related to Aging

Part One: Introduction to Clinical Interventions

"The Lee-Benner Method"

Lectures and Hands On-Experiencing

  1. Experience is often the best teacher. The Lee-Benner Method believes the best way to learn how to be an antiaging doctor is to experience the effects of being a patient yourself. Therefore, each candidate is expected to participate in this highly individualized curriculum themselves.
  2. Course Objectives:

Part Two: Basic Science Review

    I. Biochemistry with Clinical Correlations

        1. Structure of macromolecules

        2. Transmission of information

        3. Functions of proteins

       4. Metabolic pathways and their control

        5. Physiological processes

    II. Biology of Aging

        1. Free radicals in Medicine and Biology

        2. Mitochondrial actions; interactions

        3. DNA/RNA mutations

       4. Replicative senesence and telomere shortening

        5. Differences between aging and disease

        6. Post-reproductive dissociation of integrated change

        7. Age-related, rates of decline in various physiologic functions

       8. Temporal relationships associated with cyclic reproductive function

        9. Physiologic dysfunction, temporal disorder and pathology relationships

        10. Growth Hormone Deficiency (GHD)

        11. Consequences of dysfunctional GH neuroendocrine axis

       12. Pituitary dynamic tests and aging

        13. Melatonin decline with aging

        14. The Adrenal Gland

        15. Age-related DHEA-S decline

       16. The testes

        17. Testosterone response to hGH

        18. Pituitary response to LHRH

        19. The ovary

       20. Age-related bio-LH iso-electric-focusing profile changes in women

        21. The Thyroid

        22. TSH response with aging

        23. The Pancreas

       24. Oral glucose tolerance test (OGTT) in non-obese healthy males

        25. GH Neuroendocrine-axis

        26. Regulation of GH secretion

        27. Neuroendocrine change with aging

       28. GH secretion throughout life

        29. The decline of GH with aging-mechanisms

        30. Is age-related frailty an endocrine deficiency state?

        31. Functional ability with age

       32. Interventions:

             Caloric Restrictions (CR)

             Growth Hormone (GH)

                 Insulin-like Growth Factor (IGF-I)

                 GHRH; GH secretagogues (ghrelin mimetics)

                 Combinations with:

                 Each other—thyroid—pancreatic—adrenal

                 Sex steroids


        33. Adult GH deficiency—a model and a precedent

        34. GH for normal aging: first reports

        35. Chronic IGF-I GH treatment

       36. Potential for GHRH as intervention therapy

        37. What did we know previously?

        38. What don’t we know now?

        39. What should we do in the future?

Part Three: Neurobiology of Growth Hormone Deficiency and Aging

    I Historical and Current Perspectives

    II Complementary Interventions

    III Effects on Systems Physiology (Bone and Muscle)

    • Markers for bone density

    • Differential effects of GHD onset on bone mineralization

    • Temporal relationships between treatment onset and bone formation

    • Lean Body Mass effects

    • Different effects on body loci

    IV Effects on Systems Physiology (Immunity)

    • Organ sensitivity to hormone influence

    • Relationship between thymopoiesis and disease

    • Effect of GH on immune system cell types

    • Toxicity and plieotrophic effects on T cell recovery

    • Mechanism for promoting thymopoiesis

    V Secretagogue Therapy

    • Effect of GHRH on body composition

    • Influence of Estrogen

    • Production of loci for endogenous GHRPs

    • Mechanism of GH releasing action

    • Role of Somatostatin

    • Atypical effects of GH secretagogues

    • Diagnostic functions

    VI Toxicity

    • Effects on fluid retention, arthralgias, carbohydrate metabolism, etc.

    • Age relationship to toxicity

    • Cancer risk

    • Dosage relationships to risk

    • Natural conditions; acromegaly

    • Methods for measuring GH hyper-secretion

    VII Ethical and Regulatory Issues

    • Risk benefit in healthy aging persons

    • Federal restrictions against "off label" use of hGH

    • Moral dilemma in treating healthy patients

    • Art of medicine and authority to treat

    • Potential penalties

    • Research vs. Therapy

    • Informed consent in investigational processes


Part Four: Clinical Issues for the Regulation of Physiological Changes During Adult Human Aging.

The following content contains clinical practice guidelines for determining the most effective methods of diagnosing and treating these critical factors that affect adult human aging. These guidelines are a working document that reflects the state of the field at the time of presentation. Because rapid changes in all of these areas are expected, periodic revisions will be inevitable. The present recommendations may not be appropriate in all situations. Also, any decision by practitioners to apply these guidelines must be made in the context of local resources and individual patient circumstances.

  1. Somatopause
  2. Sarcopenia
  3. Controlling atherosclerosis with lipid modification strategies.
  4. Insulin resistance/the Metabolic Syndrome (MBS)
  5. Polycystic Ovary Syndrome (POS)
  6. Sex and Gender Factors: Implications for health and clinical practice
  7. Sexual function/fertility
  8. Hormone Replacement Therapy—Male & Female
  9. Mental Decline
  10. Oxidative stress/antioxidants/ nutrition
  11. Exercise
  12. Aging skin
  13. Immunomodulation
  14. Biomarkers of aging
  15. Cancer, diabetes
  16. Adrenal disorders
  17. Fibromyalgia, Chronic Fatigue Syndrome, and other related neuroimmune disorders.
  18. Stress, aging, cortisol, and growth hormone interactions and related issues.
  19. Burn-out Syndrome, and Post-Traumatic Stress Disorder
  20. Sleep disorders
  21. Hypogonadism
  22. Androgen induced hypogonadism
  23. Cognitive Behavioral Therapy (Relaxation techniques, basic psychotherapy, applied behavioral modification techniques for eating behavior, sleep disorders, sexual dysfunction disorders, etc.)
  24. Epigenetics of Genomic Regulation
  25. Tissue Engineering for Reparative Medicine


Recommended Textbooks, and Study Guides

for the LBI Fellowship Program

Physician’s Guide to Free Radicals, Immunity and Aging. Lee-Benner, Lord, World Health Foundation Press, Newport Beach, CA., 1990

Physician’s Guide to Physical Fitness. Lee-Benner, Lord, World Health Foundation Press, Newport Beach, CA., 1996

Turning Back the Aging Clock. Lee-Benner, Lord, World Health Foundation Press, Newport Beach, CA., 1997

Textbook of Biochemistry with Clinical Correlations, Fifth Edition. Devlin, Thomas, Editor, Wiley-Liss, New York, 2002

Basic Neurochemistry, Fifth Edition. Siegel, Geo, Agranoff, Bernard, Alber, Wayne, Molinoff, Perry, Editors. Raven Press, N.Y., 1994

Neuroendocrinology in Physiology and Medicine. Conn, P Michael, freeman, Marc, Editors, Humana Press, Totowa, New Jersey, 2000

Endocrinology, Fourth Edition (3 Vols.) DeGroot, Leslie, Jameson J. Larry, Editors. W.B. Saunders, Phila., PA., 2001

Users’ Guides to the Medical Literature, a Manual for Evidence-Based Clinical Practice. Guyatt, Gordan, Renme, Drummond, Editors. AMA Press, 2002

Guidelines for Exercise Testing and Prescription, Third Edition. American College of Sports Medicine, Lea & Febiger, Phila., 1986

The Heart Rate Monitor, Edwards, Sally, Fleet Feet Express, Sacramento, CA., 1997

Training Lactate Pulse-Rate. Janssen, Peter, Polar Electro Oy Pubs, Finland 1987

Practical Handbook of Human Biologic Age Determination. Balin, Arthur, CRC Press, Boca Raton, FL., 1994

Biological Aging Measurements, Clinical Applications. Dean, Ward. The Center for Biogerontology, Pensacola, Fl., 1988

Growth Hormone in Adults, Physiological and Clinical Aspects, Second Edition. Juul, Anders, Jorgensen, Jens, Editors, Cambridge University Press, U.K., 2000

The Biology of Aging. Brookbank, John, Harper & Row Press, N.Y., 1660

The Potential for Nutritional Modulation of Aging Process. Ingram, Donald, Baker, Geo., Shock, Nathan, American Health Foundation Food & Nutrition Press, Trumbull, Conn. 1988

U.S. Department of Agriculture Composition of Foods, Handbook No. 8, USDA, Washington, D.C.

Endocrinology of Aging. Morley, John, Van den Berg, Lucretia, Editors, Humana Press, Totowa, New Jersey, 2000

Hormones, Gender and the Aging Brain, the Endocrine Basis of Geriatric Psychiatry. Morrison, Mary, Editor, Cambridge Univ. Press, U.K., 2000

Aging and Male Sexuality. Schiavi, Raul, Cambridge Unive. Press, U.K., 1999

Recommended Journals

Science, published weekly by the American Association for the Advancement of Science, Wash., D.C.

Nature Medicine, published monthly by Nature Publishing Group, N.Y.

Endocrine Practice, published six times a year; the official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, Jacksonville, Fl., www.aace.com

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